Biography:

Anu T Singh has completed her PhD in tumor biology from All India Institute of Medical Science, Delhi and postdoctoral research from National Institute of Immunology, Delhi. She is the Vice President of Dabur Research Foundation (DRF). She has published and presented more than 40 research papers in peer reviewed journals & scientific meetings. She has extensive experience in the area of hair biology and screening of variety of hair products. DRF provides a range of Research Solutions in Pre-clinical Biology to national and international pharmaceutical & biotechnology companies with a comprehensive range of services for pharmacological, biological and analytical testing in therapeutic areas such as Oncology, Metabolic diseases, Inflammation, Immunomodulation, Dermatology and Gastric diseases. A comprehensive range of screening assays for studying the hair biology has been developed.

Abstract:

The hair growth cycle consists of 3 phases: growth phase (anagen phase), regression phase (catagen) and resting phase (telogen). The Dermal Papilla (DP) is the main mesenchymal component of hair follicle, which plays important role in induction of new hair-follicles and maintenance of hair growth.

Alopecia (hair loss) is a common hair disorder, especially in males. Androgens, nutritional deficiency, genetic factors, age, stress and environmental conditions contribute to alopecia. Finasteride and Minoxidil have been approved for the treatment of hair loss by the US FDA. However, the drugs have limited and transient effects, with unpredictable efficacy and side effects.

Hence, development of novel effective cosmeceuticals to prevent hair loss and enhance hair growth is an unmet need. Herbal hair growth promoters have been investigated for hair growth promoting effects. The development of potent hair growth promoters from natural ingredients has been impeded by lack of models predictive of hair growth in humans.

At Dabur Research Foundation India (DRF), we have developed a repertoire of validated screening models to assess activities of products for hair growth promotion (Figure 1). We have investigated the hair growth promoting potential of plant extracts, Androgen receptor downregulators, peptides, and growth factors secreted by human stem cells in validated rodent based models. These models are optimized to quantitate hair growth as well as the improvement in hair quality, strength & colour.

Further we have worked with in vitro and ex vivo assays that suitably represent the characteristic features of hair follicle. We have tested hair growth promoting efficacy of plant actives, herbal extracts and oils using DPCs. Whole hair organ cultures were generated to evaluate the efficacies of marketed formulations, hair oils and plant actives.

The multiparametric strategy developed at DRF for development of potent hair growth promoters along with the case studies will be discussed.

Biography:

Manu Jaggi holds a Doctorate in Cancer Biology from National Institute of Immunology, Delhi and has completed his Master’s in Pharmaceutical Sciences. He is the Chief Scientific Officer of Dabur Research Foundation (DRF). He has extensive experience in the area of skin-care biology and screening of variety of cosmeceutical agents. DRF provides a range of research solutions in preclinical biology to national and international pharmaceutical & biotechnology companies with a comprehensive range of services for pharmacological, biological and analytical testing in therapeutic areas such as Oncology, Metabolic Diseases, Inflammation, Immunomodulation, Dermatology, Hair Biology and Gastric Diseases. He holds more than 100 patents and has published and presented more than 150 research papers in peer reviewed journals & scientific meetings. A comprehensive range of screening assays for studying the skin-health and anti-aging potential has been developed.

Abstract:

The human skin is the largest organ of the integumentary system. Unhealthy or aged skin is related to many factors such as oxidative stress, loss of moisture, inflammation and degradation of proteins. With aging, there is a misbalance between the skin cells turnover and degradation of Extracellular Matrix (ECM), comprising of collagen, elastin, Hyaluronic acid (HA) and Matrix Metalloproteinase (MMPs). This results into the dermis getting thinner and reduction of skin tone and elasticity, leading to fine lines, wrinkles, blemishes, age spots and unhealthy skin. UV induced damage also results in the deleterious effects on skin, resulting into dull and wrinkled skin. Increased sebum production and skin inflammation caused by P. acnes contributes to acne. Since 2009, animal testing has been banned on chemicals to be used in cosmetics. This has facilitated the development of cell based screening models to assess anti-aging and skin health promoting potential of new cosmeceutical products. At Dabur Research Foundation (DRF) India, we have developed a panel of validated screening models to evaluate effects of novel cosmeceutical agents on human skin equivalent cell lines (Figure 1). The potential of various test items such as plant extracts, peptides, growth factors secreted by human stem cells, multivitamin complexes and essentials oils were investigated on key skin cells such as, fibroblasts, keratinocytes, melanocytes and sebocytes. Levels of collagen, elastin and HA in fibroblasts, anti-oxidant and anti-inflammatory properties in keratinocytes were examined for anti-aging potential. Further, sebostatic potential in human sebocytes and anti-blemish/skin-whitening properties in melanocytes were evaluated. The safety of test agents is tested using fibroblasts/keratinocytes and further confirmed in 3-D skin models. The multiparametric strategy developed at DRF for development of cosmeceutical products along with the case studies will be discussed.

Biography:

Mohsen Naraghi is a double-board certified Facial Plastic and Reconstructive Surgeon who was the winner of the International Award of the American Rhinologic Society (ARS) in 2005. He was also granted the International Award for Excellence in Medical Sciences in the innovation in Clinical Medicine during 2011. He was awarded the American Academy of Otolaryngology—Head and Neck Surgery Honor Award in recognition of his distinguished service on committees, scientific programs, continuing education courses and instruction courses to the Academy in 2015. He was also awarded Committee Excellence Award for his distinguished services on the humanitarian efforts committee of the American Academy of Otolaryngology—Head and Neck Surgery in 2016. Being an active member of both the American Academy of Facial Plastic Reconstructive Surgery and the American Academy of Cosmetic Surgery, he is also a fellow of the American Rhinology Society. He is the author of more than 300 articles and chapters in Rhinology and Facial Plastic Surgery including a two-volume comprehensive rhinology university textbook. His other title “Facial Plastic Surgery” was awarded as the country’s best academic book of the year in 2007.

Abstract:

The objectives of the present study are to: 1) Know the anatomic characteristics of the Middle Eastern noses, 2) Identify risk factors and pitfalls in Middle Eastern rhinoplasty, and 3) Select the best technique for each type of Middle Eastern nose. There are many factors in the nose structure that make Middle Eastern rhinoplasty as a difficult rhinoplasty procedure. Heavy, thick skin and weak cartilage support are the important parameters in the noses of this region of the world. These factors make noses to show characteristics including: Wide and large nose, long nose, drooping nose, acute nose-lip angle, deep nasal root angle and prominent arching nose. This is very important for surgeons to avoid making unnatural looks and negative influences of the operated appearance of the nose on other parts of the face. The principle of structural augmentation and making support, especially in the base of the nose is of great importance to avoid complications in the Middle Eastern noses. Indeed most patients with Middle East noses have deficiency in structural support. By the exact evaluation and facial analysis, it will be revealed that many humps are not totally excessive, and some part of the hump is evident because of the deficiency in the root and base of the nose. The false effect of inadequate projection of the nasal base is a common cause of surgical mistakes in the Middle East noses. It could be prevented by starting the correction of the nose from the base and continuing to the upper parts of the nose. In this presentation, several other important mistakes in surgery of the Middle Eastern noses will be addressed, including caudal septum, upper lateral cartilage and alar base.

Biography:

Alaa Gheita, Emeritus Professor of Plastic and Reconstructive Surgery Faculty of Medicine Cairo University Egypt .Egypt National Award of Medical Science1987 . Honorary President Aesthetic Academy of Egypt, Ex IPRAS Exco Board member 1995-2003, ISAPS National Secretary for Egypt 2004-2011, Former President Egyptian Society of Plastic Surgeons, Founder African Section in IPRAS, Honorary member French Society of Plastic Surgery. Editorial board of Aesthetic Surgery Journal and French Plastic Surgery Journal, Publications on Mammoplasty, Facial rejuvenation, Rhinoplasty, Hypertelorism, Craniosynostosis, Liposuction, Abdominoplasty and others. 

Abstract:

Introduction: In recent years a multitude of manoeuvres has been introduced in face lifting procedures, claiming a better  aesthetic result and a longer lasting effect. One of the most important and maybe the most revolutionary was the SMAS procedure following the anatomical description  by the tessier group in 1974 of the musculo aponeurotic attachment of the subcutaneous  facial layers of the face and neck. The author presents his way of SMAS cautery and some ancillary procedure on the face and neck lift to improve on the final results of facial rejuvenation.